A CCVC/CGCC research article has just been published open access in Green Chemistry (RSC), entitled “Solvent-less environmentally benign amino ester, amide, and peptide synthesis enabled by resonant acoustic mixing.” (DOI: 10.1039/d5gc04619j)

This work was carried out in the Department of Chemistry at Université de Montréal led by Nassim Maarouf-Mesli, Justin Desjardins-Michaud, Zeynab Imani, Kinshuk Ghosh, and Felix Polyak in the laboratory of Professor William D. Lubell.

The authors show that a resonant acoustic mixer (RAM) enables the formation of ester, amide, and peptide bonds by reactions at high concentration in green solvents (EtOAc, DME, 2-MeTHF) with minimal liquid waste, low epimerization, and improved process mass intensity (PMI) compared to conventional solution and ball-milling approaches.

This work offers potential for more sustainable manufacturing of peptide therapeutics to meet emerging environmental requirements in the pharmaceutical sector.

Link of the article

https://www.linkedin.com/in/nassim-maarouf-66742a195

www.linkedin.com/in/justin-desjardins-michaud-15169112a

https://www.linkedin.com/in/kinshuk-ghosh-071370187

https://www.linkedin.com/in/william-lubell-50a6756

https://www.linkedin.com/in/felix-polyak-ab28741