- by Marie Cano
- 8 December 2025
A CCVC/CGCC research article has just been published open access in Green Chemistry (RSC), entitled “Solvent-less environmentally benign amino ester, amide, and peptide synthesis enabled by resonant acoustic mixing.”
This work was carried out in the Department of Chemistry at Université de Montréal led by Nassim Maarouf-Mesli, Justin Desjardins-Michaud, Zeynab Imani, Kinshuk Ghosh, and Felix Polyak in the laboratory of Professor William D. Lubell.
The authors show that a resonant acoustic mixer (RAM) enables the formation of ester, amide, and peptide bonds by reactions at high concentration in green solvents (EtOAc, DME, 2-MeTHF) with minimal liquid waste, low epimerization, and improved process mass intensity (PMI) compared to conventional solution and ball-milling approaches.
This work offers potential for more sustainable manufacturing of peptide therapeutics to meet emerging environmental requirements in the pharmaceutical sector.
https://www.linkedin.com/in/nassim-maarouf-66742a195
www.linkedin.com/in/justin-desjardins-michaud-15169112a
https://www.linkedin.com/in/kinshuk-ghosh-071370187